FOAM Sources (Free open access medical education):
Maryland CC Project – Jennie Law MD : Hemophagocytic Lymphohistiocytosis, a critical care conundrum
Clinical characteristics, prognostic factors, and outcomes of adult patients with hemophagocytic lymphohistiocytosis Zaher K. Otrock and Charles S. Eby American Journal of Hematology, Vol. 90, No. 3, March 2015
Prognostic factors and outcomes of adults with hemophagocytic lymphohistiocytosis. Mayo Clin Proc. 2014 Apr;89(4):484-92.
Infection is the major trigger of hemophagocytic syndrome in adult patients treated with biological therapies. Brito-Zerón P, et al. Semin Arthritis Rheum. 2016.
Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Fardet L, et al. Arthritis Rheumatol. 2014.
Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis. Allen CE, et al. Pediatr Blood Cancer. 2008.
Marked hyperferritinemia does not predict for HLH in the adult population. Schram AM, et al. Blood. 2015.
Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial. Crit Care Med. 2016 Feb;44(2):275-81
Prognostic factors of early death in a cohort of 162 adult haemophagocytic syndrome: impact of triggering disease and early treatment with etoposide Arca, M., et. al. 2015 Br J Haematol, 168: 63–68